不对称的甲状腺眼睛疾病
Khizar Rana1,2, Lee Shien S Yong1,2, Devanshu Garg1,2
1Department of Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, SA, Australia.
概括
不对称的甲状腺眼病 (TED) 现在可以使用计算机断层扫描 (CT) 扫描来客观地定义,以测量眼外肌肉体积. 这种放射学方法提供了一个比目前的临床评估更可靠的方法来诊断不对称的TED.
科学领域:
- 眼科医生 眼科 眼科
- 放射学 放射学是一门学科.
- 内分泌学 在内分泌学.
背景情况:
- 甲状腺眼病 (TED) 经常表现为不对称.
- 目前对不对称TED的定义缺乏普遍接受,并依赖于主观的临床迹象.
- 需要客观的放射学标记来准确诊断不对称TED.
研究的目的:
- 用一个客观的,放射学定义来评估不对称的甲状腺眼病 (TED).
- 建立一种可靠的方法来量化TED患者的不对称性.
主要方法:
- 对TED患者的回顾性研究使用计算机断层扫描 (CT) 扫描轨道.
- 手动细分以确定每个轨道中的眼外肌肉体积.
- 通过总肌肉体积的比率 (≥1.4) 定义的不对称性;如果相反的轨道没有显示肌肉膨胀,则单边疾病.
- 与赫特尔外眼镜测量测量结果进行比较.
主要成果:
- 15%的患者 (15/100) 表现出不对称的TED,其中9人患有单边疾病.
- 没有发现不对称与年龄,性别,甲状腺状况或激素水平之间的相关性.
- 在不对称轨道上观察到异眼的显著差异;2.75毫米的异眼差异切割值显示出高精度 (AUC 0.83),用于识别放射学定义的不对称TED.
结论:
- 对不对称的TED缺乏普遍接受的定义.
- 在TED中出现不对称的临床迹象是不可靠的.
- 通过CT扫描对眼外肌肉体积的客观放射性评估提供了对不对称TED的强有力的定义.
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