性结肠炎患者开始先进治疗的血栓栓塞和心血管风险概况
Valentin Calvez1,2, Giuseppe Cuccia2, Angelo Del Gaudio2
1Medicina Interna e Gastroenterologia, IBD UNIT-CEMAD (Centro Malattie Apparato Digerente), Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
开始先进治疗的性结肠炎患者患静脉血栓栓塞 (VTE) 和心血管 (CV) 事件的风险较低. 这些发现表明,人们对Janus 激酶抑制剂存在担忧.
科学领域:
- 胃肠病学 胃肠病学
- 心脏病学 心脏病学
- 血液学 血液学 血液学
背景情况:
- 性结肠炎 (UC) 与静脉血栓栓塞 (VTE) 和心血管 (CV) 事件风险增加有关,特别是在爆发期间.
- 有关Janus酶抑制剂的内在CV和血栓塞栓风险存在担忧,但UC患者的真实数据有限.
研究的目的:
- 评估UC门诊患者开始先进疗法的血栓栓塞和心血管风险概况.
- 评估该患者群体中VTE和CV临床事件的发生率.
主要方法:
- 一项横截面研究,对300名UC门诊患者进行前性纵向随访,开始先进治疗.
- 评估了基线VTE和CV风险因素;CV风险是使用既有风险计算器计算的.
- 在27个月的中位数随访期间,对患者进行了VTE和CV事件的监测.
主要成果:
- 大多数患者的风险因子为0-1 VTE;高C-反应蛋白是常见的 (45.0%).
- 心血管风险一般低至中度,但老年患者的风险更高.
- 在随访期间,观察到静脉瘤 (1.3%) 和心血管事件 (1.3%) 的发病率较低.
结论:
- 在接受先进治疗的UC患者队列中,血栓栓塞和心血管风险较低.
- 静脉瘤和心血管瘤事件的发生率很低,这表明对Janus激酶抑制剂的担忧可能不完全适用.
- 老年UC患者表现出更高的心血管风险概况.
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