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在肥尾和薄尾羊种群中全基因组识别选择信号

Lei Gao^1,2, Yiyuan Zhang², Bin Zhang²

¹College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China.

Frontiers in genetics

|November 3, 2025

概括

绵羊进化了脂肪尾巴,作为一种适应性特征,用于饥荒生存. 基因组分析确定了与脂肪积累相关的关键基因 (PDGFD,BMP2,GLIS1,LIPE,MSRB3,TBX15),有助于低脂肪羊的繁殖.

科学领域:

* 基因组学和进化生物学
* 动物科学与繁殖
*代谢和生理学研究

背景情况:

* 肥尾羊表现出一种独特的进化适应储能,这对于在食物短缺时期的生存至关重要.
* 这一特征在养品种中仍然存在,这突显了它在绵羊进化和生理学的重要性.

研究的目的:

* 调查与羊群肥尾特征相关的遗传基础和选择特征.
* 为了确定候选基因和生物途径参与脂肪积累和脂质代谢在绵羊尾巴.
*为旨在开发低脂肪羊品种的选择性育种计划提供分子洞察力.

主要方法:

*555只绵羊样本的全基因组再测序 (30个新,525个公开).
*使用种群遗传学方法进行分析:固定指数 (F_ST),核酸多样性 (π),跨种群复合概率比率 (XP-CLR) 和同性运行 (ROH).
* 候选基因和基因本体学术语的识别和功能注释.

主要成果:

*确定了32个与胖尾特征相关的候选基因.
*突出显示了6个特定的基因 (PDGFD,BMP2,GLIS1,LIPE,MSRB3,TBX15) 对于脂肪积累和脂质代谢至关重要.
*揭示了8个与介质细胞分化,激素调节和参与脂肪沉积的组织形态发生有关的重要基因实体学术语.

结论:

* 该研究为养殖低脂肪羊提供了关键的分子标,提高了绵羊养殖的经济回报.
*研究结果有助于了解羊业的环境适应和产品开发.
*基因组洞察力支持通过有针对性的繁殖策略来推进绵羊养殖.

关键词:

这是一只肥尾大.基因本体学基因本体学选择签名选择签名羊群羊群羊群的羊群是什么意思进行全基因组再测序.

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