心肌病中的代谢干扰:对早期诊断和有针对性的干预措施的影响
Rula Al-Shahrabi1, Ghadeera Al Mansoori2,3, Muna Al-Saffar3,4
1Sharjah Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Frontiers in cardiovascular medicine
|November 3, 2025
概括
心肌病 (CM) 涉及复杂的代谢变化. 审查代谢学研究揭示了氨基酸和能量代谢中的亚型特定干扰,为疾病机制和潜在的临床应用提供了洞察力.
科学领域:
- 生物化学 生物化学
- 心脏病学 心脏病学
- 基因组学就是基因组学.
背景情况:
- 心肌病 (CM) 包含各种心肌疾病的原因不明,通常源于代谢障碍.
- 能量生产和基质使用中的代谢变化会损害心脏功能和应激反应.
- 了解这些代谢变化对于诊断和治疗各种CM亚型至关重要.
研究的目的:
- 审查使用高通量平台的代谢学研究.
- 了解不同心肌病亚型的代谢途径转移.
- 探索这些代谢干扰的临床翻译相关性.
主要方法:
- 对心肌病中的代谢学研究的系统审查.
- 分析高通量代谢组数据.
- 跨CM亚型的代谢资料的比较.
主要成果:
- 经常出现的干扰包括氨基酸代谢的改变,线粒体的氧化还原失衡和氧化应激.
- 特定的CM亚型表现出不同的代谢特征:过度缩的CM (核酸重塑),扩张的CM (克雷布斯循环中间体),限制性CM (氨基酸应激),动脉冲动的CM (脂肪酸重塑) 和TakotsuboCM (子利用).
- 代谢特征是特定于亚型的,而不是所有心肌病的普遍特征.
结论:
- 一个单一的新陈代谢特征无法涵盖所有心肌病.
- 特定亚型的代谢变化为疾病机制提供了重要的洞察力.
- 代谢学对心肌病具有诊断,预后和治疗意义,增强了临床翻译.
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