麻醉小鼠中纳贾奥克西亚纳毒素的急性心血管影响
Zaeri Sasan1, Kim Euikyung2, Fatemikia Hossein3
1Department of Pharmacology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
Archives of Razi Institute
|November 3, 2025
概括
蛇毒 (Naja naja oxiana) 在老鼠中引起显著的低血压和心率下降. 肝素和阿米诺瓜尼丁的前期治疗提供了对毒素诱导的低血压暂时的保护.
科学领域:
- 毒理学和药理学 毒理学和药理学
- 心血管生理学心血管生理学
- 病理学 病理学 病理学
背景情况:
- 蛇咬,特别是来自Naja naja oxiana的蛇咬,在伊朗很常见,导致神经症状.
- 了解N. naja oxiana毒液的血液动力学影响对于开发有效的治疗方法至关重要.
研究的目的:
- 在大鼠模型中研究由N. naja oxiana毒素引起的血液动力学异常.
- 评估阿特罗平,德克萨米他,肝素和阿米诺瓜尼丁作为前期药物的中和作用.
主要方法:
- 20只雄性Wistar大鼠被分为四组:对照组和三组毒素注射组 (300,600,1500μg/kg).
- 在毒药注射10分钟前,先前的药物 (阿特罗平,德克萨米他,肝素,阿米诺瓜尼丁) 被内注射.
- 血液动力学参数得到监测,器官 (肺,心脏,脏) 在死后进行了体病理学检查.
主要成果:
- 高剂量的N. naja oxiana毒液 (1500μg/kg) 诱导了显著的负性离子转变效应,低血压和心率下降,导致8分钟内死亡.
- 肝素和阿米诺瓜尼丁前期治疗在8分钟后显著降低了低血压,但在20分钟后没有预防死亡.
- 组织病理学揭示了肺膜壁干扰与红细胞和炎症透;其他器官显示没有异常.
结论:
- N. naja oxiana 毒液会引起显著的心血管疾病,主要是系统性血管扩张和负面无otropic 效应.
- 肝素和aminoguanidine在减轻毒素引起的低血压方面表现出部分功效.
- 进一步的研究是有必要的,以探索更高剂量的肝素和aminoguanidine可能延长存活.
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