夜班工作增加患上易怒肠综合征的风险:英国生物银行的一项前性队列研究
Shiwei Lu1, Laifu Li1, Yan Zhuang1
1Department of Gastroenterology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Frontiers in public health
|November 3, 2025
概括
经常在夜班工作会增加患上刺激性肠综合征 (IBS) 的风险. 这项研究强调了夜班工作和IBS发病率在英国大型生物银行队列中存在显著的关联.
科学领域:
- 胃肠病学 胃肠病学
- 职业健康 职业健康 职业健康
- 流行病学 流行病学
背景情况:
- 刺激性肠综合征 (IBS) 是一种普遍存在的功能性胃肠道疾病,具有相当大的健康和经济影响.
- 夜班工作在全球越来越普遍,并与各种不良健康结果有关.
- 夜班工作与发展IBS的风险之间的关系需要进一步调查.
研究的目的:
- 调查夜班工作与发生刺激性肠综合征 (IBS) 风险之间的关联.
- 量化那些经常在夜班工作的人与那些不这样做的人之间的IBS风险.
主要方法:
- 利用了英国生物库266,605名参与者的数据.
- 采用Cox比例危险回归模型来分析夜班工作与IBS发病率之间的关联.
- 进行了敏感性和子组分析,以确保发现的稳定性和通用性.
主要成果:
- 在9.03年的中位数随访期间,共发现了5218起IBS病例.
- 那些总是夜班工作的人患IBS的风险显著增加 (HR1.36; 95% CI 1.19-1.56在完全调整的模型中).
- 增加的风险在各个子组中是一致的,但在BMI≥25 kg/m2的个体中尤其明显.
结论:
- 持续的夜班工作与患上易怒肠综合征的风险更高有关.
- 研究结果表明,职业健康策略可能需要考虑夜班工作者的胃肠道健康.
- 对这种关联背后的机制进行进一步的研究是有必要的.
相关概念视频
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