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从创伤到抑郁:结构,突触,表观遗传和分子通路将早期压力与终身脆弱性联系起来

Mina Takahashi1, Richard C Shelton1,2

  • 1Department of Psychiatry, Heersink School of Medicine, University of Alabama at Birmingham, Huntsville, AL, United States.

Frontiers in psychiatry
|November 3, 2025
PubMed
概括

童年不良经历 (ACE) 可以在表观遗传上改变大脑发育,增加抑郁风险. 了解这些分子变化,包括DNA甲基化和microRNAs,是针对性干预创伤相关情绪障碍的关键.

关键词:
a-氨基-3-基-5-甲基-4-异醇酸 (AMPA) 受体滥用 滥用 滥用 滥用不良的童年经历 儿童不良的童年经历基因组学就是基因组学.谷氨酸酸盐的使用方法脑下垂体 - 垂体上腺轴微型RNAs是一种微型RNA.

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