相关实验视频
Updated: Jan 12, 2026

07:49
Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
19.9K
在没有皮肤参与的情况下,预诊断和非先进的全身巨细胞瘤有过敏反应的风险增加
Andrea Sangalli1, Valerio Pravettoni1, Mariarita Sciumè2
1General Medicine Unit, Department of Internal Medicine, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Frontiers in allergy
|November 3, 2025
概括
过敏反应在全身性乳腺细胞瘤 (SM) 和SM前是常见的,虫毒液和药物作为关键触发因素. 没有皮肤病变的患者面临更高的风险,需要仔细监测和评估.
科学领域:
- 血液学 血液学 血液学
- 过敏学 过敏学
- 免疫学 免疫学 免疫学
背景情况:
- 系统性巨细胞瘤 (SM) 患者面临过敏反应风险升高.
- 预诊断性系统性乳腺细胞瘤 (SM) 是一个未被认可的亚组,具有潜在的过敏反应风险.
研究的目的:
- 确定系统性巨细胞瘤 (SM) 和SM前患者的过敏反应患病率和危险因素.
- 为了确定与MS亚型中过敏反应相关的特定触发因素和患者特征.
主要方法:
- 成年SM和SM前患者的回顾性单心研究 (2009年1月 - 2025年5月).
- 使用统计测试 (chi-squared,Wilcoxon-Mann-Whitney,Kruskal-Wallis) 来分析人口统计,临床和实验室数据.
主要成果:
- 在162名患者中,有18%的患者经历过敏反应;海门虫毒 (51.7%),药物 (27.6%) 和异常 (20.7%) 是主要的触发因素.
- 过敏反应的患病率因MS亚型而异,在SM前,BMM和ASM中患病率更高.
- 缺少皮肤病变和男性性别是危险因素;黄蜂刺史增加了毒素诱导的过敏反应的风险.
结论:
- 过敏反应在被诊断和预诊断的MS中都是一个重大问题.
- 触发因子因亚型而异:黄虫毒液在惰的形式,药物在先进的SM.
- 没有皮肤病变的患者或对黑虫毒素敏感的患者需要谨慎监测和风险评估.
相关概念视频
Allergic Reactions
32.0K
Overview
32.0K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
1.7K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.7K
Allergic Drug Reactions
1.3K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.3K
Hypersensitivities
7.2K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.2K
Asthma: Pathogenesis and Management
1.2K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.2K
Cross-reactivity
32.8K
Overview
32.8K

