系统性红斑狼患者骨 necrosis 的危险因素:一个元分析
1Department of Internal Medicine, Xianju Hospital of Traditional Chinese Medicine, Taizhou, Zhejiang, China.
Frontiers in medicine
|November 3, 2025
概括
年龄较小,糖尿病,高血压,关节炎,雷诺氏现象和环胺使用是系统性红斑狼 (SLE) 患者骨髓缩的关键危险因素. 本元分析确定了理解和潜在地预防SLE患者这种严重并发症的关键因素.
科学领域:
- 类风湿病学 类风湿病学
- 临床医学 临床医学
- 流行病学 流行病学
背景情况:
- 骨髓缩是系统性红斑狼 (SLE) 患者的一个重要并发症.
- 识别风险因素对于SLE患者的早期干预和管理至关重要.
- 之前的研究结果各不相同,需要进行全面的元分析.
研究的目的:
- 进行元分析,以确定和量化与SLE诊断的患者骨髓缩相关的风险因素.
- 为了解SLE骨髓瘤多因素病因提供一个综合的证据基础.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,Cochrane Library) 进行了系统的文献搜索,截至2024年12月1日.
- 包括的研究是病例控制或队列设计,重点关注SLE患者的骨髓缩发生.
- 数据分析使用Stata 15.0进行,研究质量通过纽卡斯尔-太华尺度 (NOS) 进行评估.
主要成果:
- 分析包括14篇文章,包括3890名患者.
- 年龄较小 (SMD = -0.23),糖尿病 (OR = 1.78),高血压 (OR = 1.33),关节炎 (OR = 1.57),雷诺现象 (OR = 1.76) 和环胺使用 (OR = 2.24) 被确定为显著的危险因素.
- 对所有已识别的风险因素的置信区间 (CI) 具有统计学意义.
结论:
- 年龄较小,高血压,糖尿病,关节炎,雷诺氏现象和环胺使用被证实是SLE患者骨髓缩的独立危险因素.
- 这些发现突出了特定的患者特征和治疗暴露,这需要在SLE管理中密切监测.
- 进一步的研究可以集中在针对这些已识别的风险因素的预防策略上.
相关概念视频
Nephrotic Syndrome I : Introduction
486
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
486
Factors Affecting the Risk of Infection
13.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.2K
Osteoclasts in Bone Remodeling
3.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.9K
Factors Affecting Protein-Drug Binding: Patient-Related Factors
298
Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
298


