相关实验视频

Updated: Jan 12, 2026

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

向与瘤相关的中性粒细胞:在肺癌免疫治疗中,这是一个有前途的策略

Yongjun Wang¹, Li Wang¹, Zexu Wang¹

¹Department of Respiratory and Critical Care Medicine, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu 210002, China.

Cancer pathogenesis and therapy

|November 3, 2025

概括

中性粒细胞曾经被认为只能帮助瘤生长,在肺癌中显示出双重作用. 了解这些与瘤相关的中性粒细胞为肺癌免疫治疗提供了新的途径.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
细胞生物学细胞生物学

背景情况:

肺癌是全球癌症死亡的主要原因,目前的治疗方法包括手术,化疗,放射治疗和免疫治疗.
现有的免疫疗法主要针对T细胞和自然杀伤细胞 (NK细胞),使得针对中性粒细胞的治疗方法发展不到.
中性粒细胞,传统上被视为终端分化的免疫细胞,现在被认为是一种具有多样性功能的异质群体.

研究的目的:

探索瘤相关中性粒细胞 (TAN) 在肺癌进展中的复杂作用.
研究TANs对瘤控制和肺癌免疫疗法的影响.
为了深入了解中性粒细胞异质性和瘤微环境中的功能.

主要方法:

这是一篇综述性文章,综合了有关肺癌中性粒细胞的现有研究.
在文献中搜索和分析调查中性粒细胞招募,功能和肺癌异质性的研究.
对TANs.的前瘤和抗瘤活动的证据的检查.

主要成果:

最初被认为促进瘤生长,但TANs表现出上下文依赖的抗瘤功能,在某些肺癌情景中抑制早期生长和转移.
TANs的功能可塑性表明,它们可以作为肺癌的促进者或抑制者,这取决于特定的瘤微环境.
这种异质性凸显了针对中性粒细胞的潜力,用于新的肺癌治疗策略.

结论:

与瘤相关的中性粒细胞在肺癌中具有双重作用,为治疗干预提供了挑战和机会.
对TAN异质性和功能的进一步研究对于开发有效的基于中性粒细胞的肺癌免疫疗法至关重要.
向中性粒细胞是寻求新型肺癌治疗的有希望但尚未发展的前沿.

关键词:

免疫治疗是一种免疫疗法.肺癌是一种肺癌.中性粒细胞中性粒细胞.瘤微环境是一个微环境.与瘤相关的中性粒细胞

更多相关视频

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Published on: June 19, 2015

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Published on: January 19, 2019

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...