持续的亚临床炎症和在越南登革热和败血症后的长期功能和认知结果
Angela McBride1,2, Nguyen Lam Vuong1,3, Huynh Thi Le Duyen1
1Dengue and Emerging Infection Research groups, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Open forum infectious diseases
|November 3, 2025
概括
越南的登革热休克 (DS) 和败血症休克 (SS) 的幸存者经历了持续的炎症. 虽然DS幸存者表现出认知恢复,SS幸存者持续认知障碍和炎症.
科学领域:
- 重症监护医药重症监护医药重症监护医药重症监护医药
- 传染病 传染病 传染病
- 关键护理结果的结果.
背景情况:
- 没有先前的研究研究了越南登革热休克 (DS) 和败血症休克 (SS) 幸存者的长期结果.
- 缺乏对功能性,认知性,炎症性和内皮连续体的关注.
研究的目的:
- 评估越南DS和SS的成年幸存者的功能,认知,炎症和内皮结局.
- 建立一个基线,以了解后震复恢复和潜在的长期并发症.
主要方法:
- 对成年DS和SS幸存者的前性观察研究.
- 医院出院后的随访,出院后的1,3个月和6个月.
- 评估生活质量 (EQ-5D-5L),认知功能 (MoCA),内皮功能 (EndoPAT) 和炎症/内皮生物标志物 (IL-6,费里丁,Ang1,Ang2,VCAM-1). 评估生活质量 (EQ-5D-5L),认知功能 (MoCA),内皮功能 (EndoPAT),以及炎症/内皮生物标志物 (IL-6,费里丁,Ang1,Ang2,VCAM-1).
主要成果:
- DS幸存者报告生活质量高,3个月后认知功能正常化.
- 幸存者生活质量较差,认知障碍持续 (MoCA分数低于正常值).
- DS和SS的幸存者在出院后呈现高IL-6和费里水平,表明持续的炎症,其中38%的DS和62%的SS幸存者在6个月后呈现高费里水平.
结论:
- 这项研究是首次报告越南的DS和SS后持续的亚临床炎症.
- 结果突出了DS和SS幸存者之间的差异性恢复模式,特别是在认知功能方面.
- 需要进一步的研究,以阐明持续性炎症后冲击的持续时间和临床影响.
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