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基于萨卡迪反应时间的青光眼跟踪生物标志物:一项受控临床研究

Alexander Sverstad^1,2, Bjørn André Helland-Hansen¹, Olav Kristianslund³

¹Centre for Eye Research and Innovative Diagnostics, Oslo University Hospital (OUS), Ullevål, Oslo, Norway.

Frontiers in ophthalmology

|November 3, 2025

概括

使用新型Bulbicam (BCAM) 装置的分离反应时间 (SRT) 在区分青光眼 (GLA) 与健康对照 (HC) 中显示出高的有效性和可靠性. 许多SRT变量是早期GLA检测的潜在生物标志物.

科学领域:

眼科医生眼科眼科
神经科学是一个神经科学.
生物医学工程生物医学工程

背景情况:

玻璃眼 (GLA) 是不可逆转的失明的主要原因.
早期检测和监测对于管理GLA.至关重要.
新型眼睛追踪设备为改进的诊断工具提供了潜力.

研究的目的:

为了评估来自Bulbicam (BCAM) 设备的萨卡迪反应时间 (SRT) 变量的有效性和可靠性.
为了区分早期至中度青光瘤 (GLA) 患者与健康对照者 (HCs).
通过使用BCAM识别GLA的潜在生物标志物.

主要方法:

一项受控的临床研究包括18名GLA患者和18名年龄相匹配的HC患者.
参与者接受了BCAM视野 (VF) 测试,在58个地点测量SRT.
分析了群体差异,重复性和稳定性的变量,并将VF位置汇总起来用于生物标志物评估.

主要成果:

在44/58位置 (最糟糕的眼睛) 和42/58位置 (最好的眼睛) 中,在GLA和HC之间发现了显著的SRT差异 (p ≤0.05).
由于显著的差异,可重复性和稳定性,八个集群,所有象限和整个VF SRT平均值/SD被评为BCAM生物标志物.
在22个BCAM VF测试变量中,有19个显示出作为GLA生物标志物的潜力.

结论:

大多数来自BCAM的SRT变量可以区分青光眼和HCs.
这些变量显示出足够的可靠性和稳定性用于临床应用在GLA诊断.
作为一种用于识别GLA生物标志物的工具,BCAM显示出了前景.

关键词:

协议指数协议指数生物标志物生物标志物眼睛运动周长度周长度玻璃眼 glaucoma 玻璃眼玻璃眼玻璃眼玻璃眼可靠性的可靠性萨卡迪克反应时间稳定性指数稳定性指数视觉现场测试视觉现场测试

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