右心房收缩菌株与心脏移植后患者的临床显著细胞排斥有关
Andreas J Rieth1,2, Isabella Fest1,2, Katharina Classen3
1Department of Cardiology, Kerckhoff-Klinik, Justus Liebig University Giessen, Bad Nauheim, Germany.
概括
心脏移植 (HTx) 后的应变回声心脏图 (SE) 显示右心房收缩应变 (RASct) 可以帮助检测急性细胞排斥 (ACR). 这种方法可以排除HTx患者的亚临床ACR.
科学领域:
- 心脏病学 心脏病学
- 移植医学 移植医学 移植医学
- 医疗成像医学成像
背景情况:
- 应变回声心电图 (SE) 用于心脏移植 (HTx) 监测.
- 在检测HTx后的急性细胞排斥 (ACR) 中,对心房应变作用的数据有限.
研究的目的:
- 为了比较心室和心房应变在HTx后识别ACR中的重要性.
- 评估与ACR相关的SE参数的实用性.
主要方法:
- 在移植后一年内,对52名HTx患者进行内心肌组织活检 (EMB) 的回顾性分析.
- 评估了SE参数 (心室和心房应变) 和由EMB确定的ACR严重程度之间的关系.
- 在23名HTx患者的单独组中验证了这些发现.
主要成果:
- ACR (≥中度) 与右心室自由壁应变和右心房收缩应变 (RASct) 的减少有关.
- -9.3%的RASct截止值显示了100%的灵敏度和79%的特异性,用于检测≥中度ACR.
- 在左心室或心房应变方面没有发现显著的关联.
结论:
- 减少右心室应变和RASct与HTx后的ACR有关.
- 右心房应变分析,特别是RASct,显示出在心脏移植受体中排除亚临床ACR的前景.
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