交叉振幅调制和复合振幅调制用于非线性对比增强超声成像纳米气泡的超声成像
Y U Weng1,2, Luke Coulter3, Muhammad Saad Khan1,2
1Department of Physics, Faculty of Science, Toronto Metropolitan University, Toronto, ON M5B 2H3, Canada.
概括
两种振幅调制技术,交叉振幅调制 (xAM) 和复合振幅调制 (cAM),可以增强纳米泡 (NB) 介导的对比增强超声波 (CEUS) 成像. xAM提高了图像清晰度,而cAM为血管流动动力学提供了高速率.
科学领域:
- 超声波成像 超声波成像
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
背景情况:
- 非线性对比增强超声波 (CEUS) 成像利用纳米泡 (NBs) 进行增强的微血管可视化和分子成像.
- 广度调制 (AM) 技术为NB介导的CEUS提供了潜在的改进.
研究的目的:
- 探索和比较两个AM技术:交叉振幅调制 (xAM) 和复合振幅调制 (cAM).
- 评估它们在增强NB介导的CEUS成像能力方面的有效性.
主要方法:
- 在Vevo F2超声波系统上测试xAM和cAM,使用Vevo高级数据采集 (VADA) 模式.
- xAM采用三事件脉冲序列与交叉传播的平面波束来隔离NB信号.
- cAM 结合了平面波复合和振幅调制以获得高率.
主要成果:
- 与B模式相比,xAM显著提高了对比度与噪声比率 (CNR) 和对比度与组织比率 (CTR) 超过10倍.
- cAM实现了706Hz的率,比xAM快100倍多,但CNR和CTR降低了50%.
- 在模仿组织的血管幻影中使用了10^9 NBs/mL的NBs.
结论:
- xAM在NB介导的CEUS中增强了成像清晰度和对比度.
- cAM提供高率,对于跟踪血管流动动力学至关重要.
- 这些技术为临床前和临床应用提供了多功能成像框架.
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