终身结合:从脊椎动物生理学到人类疾病的皮质类固醇结合球蛋白
Philippe Le Rouzic1, Karine Rousseau2
1Sorbonne Université, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche Saint-Antoine (CRSA), Paris, France.
Frontiers in endocrinology
|November 3, 2025
概括
皮质类固醇结合型全球蛋白 (CBG) 在脊椎动物中运输葡萄糖皮质素 (GC),调节压力反应. CBG水平和功能的变化与生理状态和疾病有关,这表明了治疗潜力.
科学领域:
- 内分泌学和神经内分泌学.
- 生物化学和分子生物学
- 比较生理学比较生理学
背景情况:
- 下垂体-垂体-上腺 (HPA) 轴通过葡萄糖皮质体 (GC) 调节压力反应.
- 皮质类固醇结合型环球蛋白 (CBG),也称为转皮质素,在血中结合并运输GC,调节其生物利用性.
- CBG是SERPIN家族 (SERPINA6) 的成员,在脊椎动物物种中表现出不同的变异.
研究的目的:
- 审查脊椎动物中CBG的发现,表征和测量.
- 探索CBG的生理变异和功能.
- 突出CBG改变对人类的病理相关性和潜在的治疗应用.
主要方法:
- 对CBG发现,表征和测量研究的文献综述.
- 对不同生理和病理条件下的CBG度变化研究的分析.
- 对CBG功能的当前知识的综合,包括运输,储存和受体相互作用.
主要成果:
- 在生命历史上各个阶段 (如怀孕,冬眠) 和应对极端条件 (如食物剥夺) 时,CBG水平波动.
- 除了GC运输之外,CBG还起着至关重要的作用,可能充当储库,并通过内细胞化介导GC的内部化.
- 人类的CBG缺陷与内分泌和促炎性疾病有关,这强调了其功能重要性.
结论:
- CBG是脊椎动物应激反应系统中的重要蛋白质,具有多种功能和显著的生理相关性.
- 了解CBG变异和功能,可以了解各种病理.
- 在内分泌和炎症性疾病中,CBG具有作为治疗点的潜力.
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