相关实验视频

Updated: Jul 1, 2026

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Published on: March 10, 2015

代谢物和免疫细胞调解了肠道微生物群和骨肉瘤之间的因果关系:孟德尔的随机化研究

Guanjun Chen¹, Zhenyu Song², Imtiaz Abdullah³

¹Affiliated Hospital of Guilin Medical University Guilin Guangxi China.

Health science reports

|November 3, 2025

概括

这项研究揭示了肠道微生物群,血代谢物和免疫细胞显著影响骨髓瘤 (OS) 的发展. 特定的微生物通路和CMPF等代谢物,以及免疫细胞的变化,与OS风险有关.

科学领域:

在瘤学瘤学.
微生物组研究微生物组研究
代谢学代谢学代谢学
免疫学免疫学免疫学

背景情况:

骨髓瘤 (OS) 是一种具有高转移潜力的原发性骨癌.
肠道微生物群 (GM) 对OS发展的影响尚不清楚.
研究转基因,血代谢物,免疫细胞和OS之间的相互作用至关重要.

研究的目的:

使用孟德尔随机化 (MR) 探索肠道微生物群,血代谢物,免疫细胞和骨肉瘤 (OS) 之间的因果关系.
识别与OS风险相关的特定微生物特征,代谢物和免疫细胞表型.
阐明转基因-OS轴中代谢物和免疫细胞的调解作用.

主要方法:

利用大规模的全基因组协会研究 (GWAS) 对转基因,血代谢产物,免疫细胞和OS的总结数据.
应用了一种双样本的门德尔随机化 (MR) 方法,与逆方差加权 (IVW) 和MR-Egger方法.
进行调解分析,以评估转基因通过代谢物和免疫细胞对OS的间接影响.

主要成果:

确定了六种与OS因果相关的肠道微生物特征,包括氨基酸代谢途径 (风险增加) 和细菌家族 (保护性).
发现了12种与OS相关的血代谢物,其中3 - 碳氧 - 4 - 甲基 - 5 - - 2 - furanpropanoate (CMPF) 具有保护作用.
观察到*Flavonifractor*属与OS风险增加之间的关联,部分由CX3CR1+单细胞介导,并确定了与OS相关的9种免疫细胞表型.

结论:

提供了肠道微生物群,血代谢物和免疫细胞在骨髓瘤发育中的关键作用的证据.
突出了特定的微生物通路,代谢物 (例如,CMPF) 和免疫细胞子集作为OS病原发生的潜在因素.
表明肠道微生物群,宿主新陈代谢,免疫力和骨髓瘤进展之间的复杂相互作用.

关键词:

门德尔的随机化我们的肠道微生物群.免疫细胞免疫细胞骨质肉瘤是骨质肉瘤的一种疾病.血代谢产物中的血代谢产物

更多相关视频

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Published on: March 12, 2018

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

相关概念视频

The Oral Microbiota

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...

Dysbiosis of the Gut Microbiota

Dysbiosis of the Gut Microbiota

The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...

Microbiota Modulation by Antibiotics

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...