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通过双频超声波进行增强的光声疗法

Yuchen Song, Shuang Wei, Haibin Zou¹

¹Beckman Laser Institute, University of California Irvine, Irvine, California 92612, USA.

APL bioengineering

|November 3, 2025

概括

双频超声波增强了抗血管和血栓溶解治疗的光声疗法 (PST). 这种新的方法减少了声能,同时提高了治疗效率,为临床应用铺平了道路.

科学领域:

生物医学工程生物医学工程
声学物理声学物理
医疗成像医学成像

背景情况:

光声疗法 (PST) 结合了超声波和激光,用于抗血管和血栓溶解治疗.
目前的PST方法使用单频超声波,需要高声能,有效性有限.
由于高能耗和低于最佳治疗结果,PST的临床转化受到阻碍.

研究的目的:

引入和评估双频超声波方法,以提高PST的疗效.
为了减少有效PST所需的声能.
评估双频PST在临床应用中的潜力.

主要方法:

在双频超声波下理论建模气泡动力学.
使用ex vivo血管和凝块幻象对双频PST的实验性评估.
使用子模型进行体内验证.

主要成果:

双频超声波与单频超声波相比,显著增强了化活动.
通过双频方法观察到血栓溶解和抗血管效率的改善.
在保持或提高治疗效率的同时,可以实现减少声能.

结论:

双频超声波是改善PST的一个有希望的策略.
这种方法为抗血管和血栓溶解应用提供了更高的效率和更低的能量需求.
经过验证的可行性突出显示了双频PST临床转换的潜力.

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