增长分化因子15在心力衰竭与保存的喷射分数的诊断和预后影响:系统性审查和元分析
Iwan Dakota1,2, Matthew Aldo Wijayanto1,3, Annisa Salsabilla Dwi Nugrahani4
1National Cardiovascular Center Harapan Kita, West Jakarta, Jakarta, Indonesia.
PeerJ
|November 3, 2025
概括
增长差异化因子-15 (GDF-15) 显示出作为心力衰竭的生物标志物具有保留喷射分数 (HFpEF) 的承诺. 较高的GDF-15水平与较差的结果有关,包括死亡率和住院治疗.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 炎症研究 炎症研究
背景情况:
- 增长差异化因子-15 (GDF-15) 是一种与慢性炎症和氧化应激相关的新兴生物标志物.
- 它显示了潜在的诊断和预后意义心力衰竭与保存的喷射分数 (HFpEF).
研究的目的:
- 评估GDF-15在识别HFpEF时的诊断准确性.
- 评估GDF-15在HFpEF患者死亡率和住院病例方面的预后价值.
主要方法:
- 在PubMed,Scopus和ScienceDirect进行了系统的文献搜索.
- 包括12项观察性研究,涉及5696名HFpEF患者,使用纽卡斯尔-太华尺度评估质量.
- 用随机效应模型进行了元分析,并进行了灵敏度分析以确保稳定性.
主要成果:
- 在HFpEF患者中,GDF-15水平显著升高 (总体MD:647.60 pg/mL).
- GDF-15显示出良好的诊断准确性 (AUC:0.82),并且表现优于常规生物标志物.
- 升高的GDF-15与全因死亡率 (HR: 1.46) 和心力衰竭住院治疗 (HR: 1.76) 的风险增加有关.
结论:
- GDF-15是诊断HFpEF的一个有价值的生物标志物.
- 较高的GDF-15水平表明预后更差,与HFpEF的死亡率和住院风险增加相关.
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