与代谢功能障碍相关的脂肪性肝病的肝外表现:最新的临床概述
Chia-Hsun Tsai1,2, Tsung-Hsing Hung2,3, Tuck-Siu Wong1,2
1Center for Digestive Medicine, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan.
Tzu chi medical journal
|November 3, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一种常见的肝脏疾病,与代谢问题有关. 它显著增加心血管疾病,脏疾病,糖尿病和癌症的风险,影响整体健康.
科学领域:
- 肝病学和代谢医学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是全球最常见的肝病.
- 它与代谢综合征的组成部分如肥胖,胰岛素耐药性,2型糖尿病和脂质失调症密切相关.
- MASLD的谱范围从简单的肥胖症到渐进的肥胖肝炎,纤维化,肝硬化和肝细胞癌.
研究的目的:
- 为提供与MASLD相关的关键肝外疾病的概述.
- 突出这些共同疾病在MASLD患者的临床意义.
- 为了强调MASLD的多系统性.
主要方法:
- 审查有关MASLD及其肝外表现现的当前文献.
- 综合有关MASLD与心血管疾病,慢性病,癌症,内分泌疾病,肌肉骨问题和睡眠呼吸暂停之间的关联数据.
- 讨论MASLD对死亡率和治疗结果的影响.
主要成果:
- MASLD是一种系统性疾病,与心血管疾病,慢性病和各种癌症 (结肠直肠,胰腺,乳腺) 的风险增加有关.
- 常见的并发症包括甲状腺功能低下症,多囊卵巢综合征,肉,骨质疏松症和阻塞性睡眠呼吸暂停.
- 纤维化严重程度是死亡率的关键预测指标;心血管疾病和癌症是导致死亡的主要原因.
结论:
- MASLD显著影响多个器官系统,增加主要非肝脏疾病的风险和进展.
- 以患者为中心的多学科方法对于管理MASLD及其相关并发症至关重要.
- 虽然像resmetirom这样的新疗法出现了,但生活方式的修改仍然是MASLD管理的基础.
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