老年人营养风险指数与美国糖尿病病老年人心血管和全因死亡率的关联
Chun Sun1, Kun Gao1, Keyun Liu1
1Department of Interventional Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Journal of diabetes research
|November 3, 2025
概括
较低的老年营养风险指数 (GNRI) 评分表明,糖尿病病 (DN) 的老年患者的全因死亡风险更高. 这种关联在男性中更为明显,但对心血管疾病 (CVD) 死亡率没有发现显著的联系.
科学领域:
- 老年学是一门学科.
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
背景情况:
- 患有糖尿病病 (DN) 的老年患者面临显著的死亡风险.
- 营养状况是影响该人口健康结果的关键因素.
- 老年营养风险指数 (GNRI) 是评估营养风险的工具.
研究的目的:
- 调查GNRI与全因和心血管疾病 (CVD) 死亡率在美国老年DN患者之间的关联.
- 确定GNRI是否可以作为这一人口群中的死亡率预后指标.
主要方法:
- 分析了1790名老年糖尿病病患者的队列.
- 参与者被分为三个GNRI组:中度/重度营养不良风险 (<92),低风险 (92-98) 和没有风险 (>98).
- 考克斯比例危险回归和竞争性风险分析被用来评估死亡风险.
主要成果:
- 在11724人年中,共有914名 (51.1%) 患者因各种原因死亡,274名 (15.3%) 患者因心血管疾病死亡.
- 患有中度/重度营养不良风险 (GNRI <92) 的患者有143%的全因死亡风险增加 (HR 2.43).
- 与没有风险组相比,低风险患者 (GNRI 92-98) 患有全因死亡风险增加了56% (HR 1.56);与心血管疾病死亡率没有发现有意义的关联.
- 性别分析显示,中度/重度风险组内的男性有较高的全因死亡风险.
结论:
- 较低的GNRI得分与老年糖尿病病患者全因死亡率的增加有显著关联.
- 在这个特定的患者群体中,GNRI可能是评估死亡风险的有价值的预后工具.
- GNRI与死亡率之间的关联似乎取决于性别,男性显示出更明显的风险.
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