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结直肠癌手术后术后肠道微生物群的变化:基于切除部位的比较研究
Yutaka Hattori1, Tadashi Fujii2,3,4, Takumi Tochio2,3,4
1Department of Surgery, Fujita Health University, Toyoake, Japan.
Journal of the anus, rectum and colon
|November 3, 2025
概括
结肠直肠癌手术改变了肠道细菌,右侧结肠切除导致了最显著的变化. 这些微生物变化可能会影响患者的康复和复发风险.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 大肠直肠癌 (CRC) 需要手术切除,这是主要的治疗方法.
- 多种手术对肠道微生物群和术后结果的影响需要进一步研究.
研究的目的:
- 为了研究三种不同的CRC切除类型的肠道微生物群变化:右侧集体切除 (RSC),左侧集体切除 (LSC) 和低前切除 (LAR).
主要方法:
- 来自34名接受治疗切除的CRC患者的便样本使用16S rRNA基因扩增序列测序进行了分析.
- 在手术组和85名健康对照组之间比较了微生物群概况.
主要成果:
- 手术组显示了与对照组显著的肠道微生物群偏差.
- RSC导致了最大的α多样性减少,可能是由于大脑门损失.
- RSC减少了有益的细菌 (例如, *Faecalibacterium prausnitzii*) 和增加了 *Escherichia coli*,表明了促炎性转变. 富含LSC和LAR *Akkermansia muciniphila*,可能增强肠道屏障功能.
结论:
- 切除CRC会诱导特定部位的肠道微生物群变化.
- 这些变化可能会影响术后炎症,新陈代谢和癌症复发.
- 针对微生物组的策略可以改善CRC患者的术后结果.
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