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Updated: Jan 12, 2026

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人类诱导的多能干细胞衍生心肌细胞用于疾病建模和药物发现

Taijun Moriwaki1,2, Hidenori Tani1, Shugo Tohyama1,2,3

  • 1Department of Clinical Regenerative Medicine, Fujita Medical Innovation Center, Fujita Health University, Ohta, Tokyo, Japan.

Frontiers in bioengineering and biotechnology
|November 3, 2025
PubMed
概括

人类诱导的多能干细胞 (hiPSCs) 为疾病研究和药物发现提供了强大的工具. 进展正在克服衍生性心肌细胞 (hiPSC-CMs) 的不成熟性,提高它们在模拟疾病中的实用性并加速治疗开发.

关键词:
这是心脏器官的器官.疾病建模 疾病建模发现药物的发现.工程心脏组织的工程心脏组织.人类诱导的多能干细胞干细胞.

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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