从评估系统性硬化症相关的雷诺现象与指甲毛细膜镜的融合有效性的洞察力
Krishnasai Abhishek Madathanapalli1, Areeka Memon1, Manvitha Nadella1
1Section of Rheumatology, Allergy & Immunology, Yale School of Medicine, New Haven, CT, USA.
Rheumatology advances in practice
|November 3, 2025
概括
系统性硬化症相关雷诺现象评估 (ASRAP) 问卷显示了构造的有效性. 较高的ASRAP得分与系统性硬化症患者的指甲毛细血管检查特异性相关.
科学领域:
- 类风湿病学 类风湿病学
- 皮肤病学 皮肤病学
- 血管医学 血管医学
背景情况:
- 系统性硬化症相关的雷诺现象 (SSc-RP) 显著影响患者的生活质量.
- 最近开发的系统性硬化症相关雷诺现象评估问卷 (ASRAP) 需要验证.
- 爪毛细膜镜 (NFC) 是SSc的关键诊断工具,可以揭示微血管变化.
研究的目的:
- 为了评估ASRAP问卷的收有效性.
- 评估ASRAP得分,患者人口统计和全身性硬化症 (SSc) 患者的指甲毛细分镜 (NFC) 发现之间的关联.
主要方法:
- 七十五名SSc患者填写了ASRAP问卷.
- 进行了指甲毛囊镜检查 (NFC),并通过盲目评估人员对"硬质皮质模式"和特定异常进行了图像评估.
- 获得了半定量NFC分数,并使用统计分析 (相关性,回归) 来检查ASRAP,NFC和临床数据之间的关系.
主要成果:
- 与男性相比,女性的ASRAP分数更高 (11.2分差).
- 在ASRAP得分和半定量NFC得分之间发现了弱相关性 (斯皮尔曼的σ = 0.23,P=0.05),冬季的相关性中等 (σ = 0.36,P=0.04).
- 在NFC上,毛细血管扩张和毛细血管脱落的患者的ASRAP得分显著更高 (分别为6.1和6.8分).
结论:
- 在评估SSc-RP时,ASRAP问卷显示了构造的有效性.
- 研究结果支持在临床实践中使用ASRAP来评估SSc-RP,更高的得分表明更严重的症状或微血管变化.
- ASRAP分数与特定的NFC异常之间的关联为SSc-RP提供了机制性的洞察力.
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