焦油DNA结合蛋白43,一种蛋白质病变,在COVID-19受试者中偏好嗅觉结构
Sylwia Libard1,2, Irina Alafuzoff2
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Journal of Alzheimer's disease reports
|November 3, 2025
概括
COVID-19感染可能会影响嗅球和通道中的TDP43和α-synuclein等蛋白质病变,这可能解释了持续的嗅觉障碍. 这项研究检查了死后脑组织中的这些蛋白质变化.
科学领域:
- 神经科学是一个神经科学.
- 病理学 病理学 病理学
- 传染性疾病 传染性疾病
背景情况:
- 嗅觉障碍 (OI) 是神经退行性疾病 (ND) 和COVID-19的早期指标.
- 与ND相关的蛋白质病变包括粉样β (Aβ),高酸化 (HPτ),α-synuclein (α-syn) 和TDP43.3.
- COVID-19对嗅球和嗅道 (OB/OT) 中这些蛋白质病变的影响尚不清楚.
研究的目的:
- 调查具有或没有COVID-19感染史的个体的大脑和OB / OT中的ND相关蛋白质病变的存在.
- 为了比较COVID-19患者和对照患者在OB/OT中的特定蛋白质病变 (HPτ,Aβ,TDP43,α-syn) 的流行率.
主要方法:
- 从32名COVID-19受试者和10名对照人群中分析了死后脑组织和OB / OT样本.
- 样本被评估为各种蛋白质病变,炎症标记物和SARS-CoV-2尖端蛋白.
主要成果:
- 虽然HPτ和Aβ在两组中都存在,但TDP43在38%的COVID-19患者的OB / OT中发现,但在对照组中缺席.
- 在34%的COVID-19患者的OB/OT中观察到α-synuclein (α-syn),而在对照组中为60%,其中一些COVID-19病例缺乏大脑α-syn.
- 在COVID-19患者的OB / OT中检测到TDP43,即使在他们的脑组织中缺席,与对照不同.
结论:
- COVID-19感染与嗅球和嗅道中TDP43和α-syn蛋白质病变的存在有关.
- 这些发现表明COVID-19和OB / OT中的特定蛋白质病变之间存在潜在联系,这可能导致慢性嗅觉功能障碍.
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