功能性便秘的全面微生物和临床分析:对年龄和便秘亚型进行分层比较研究
Hui-Ting Zhu1, Hui-Fen Wang1, Qin Zhang1
1Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China.
World journal of gastroenterology
|November 3, 2025
概括
肠道微生物群的组成因年龄和功能性便秘 (FC) 的便秘亚型而异. 了解这些差异对于开发针对肠道菌群调节的个性化治疗方法至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 遗传学 遗传学 是一个
背景情况:
- 肠道微生物群失生症与功能性便秘 (FC) 的发病有关.
- 目前针对肠道菌群的治疗方法显示出不同的疗效.
- 对年龄和FC亚型如何影响肠道微生物群的有限理解阻碍了个性化干预.
研究的目的:
- 分析肠道微生物群概况,按年龄和FC亚型分层分层.
- 为了确定与FC患者的微生物组成相关的因素.
主要方法:
- 来自92名FC患者和34名对照者的便样本的16S rRNA基因测序.
- 根据年龄 (年轻人,中年人,老年人) 和亚型 (正常通行,缓慢通行便秘[STC],排便障碍[DD],混合) 分类的FC患者.
- 跨组微生物组成的比较和与临床参数的相关性.
主要成果:
- 微生物的丰富性和多样性随着年龄的增长而减少.
- 在各个年龄组和FC亚型中观察到不同的微生物特征.
- 年轻的FC患者的门压力较高;老年患者的有益细菌较多;中年患者的炎症性细菌较多.
- STC显示微生物多样性高于DD,特定的种类与运输速度有关.
结论:
- 在各个年龄和FC亚型之间存在肠道微生物群组成和功能的显著差异.
- 这些发现表明FC的病理生理学异质性.
- 提供了精确诊断和基于微生物群的FC治疗的基础.
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