纳米技术用于骨科手术中的疼痛管理
Emerito Carlos Rodriguez-Merchan1, Javier De Andres-Ares2, Alberto D Delgado-Martinez3
1Department of Orthopedic Surgery, Hospital Universitario La Paz-IdiPaz, Madrid 28046, Spain. ecrmerchan@hotmail.com.
World journal of orthopedics
|November 3, 2025
概括
纳米技术平台有效控制骨科手术后的术后疼痛. 这些先进的药物输送系统,包括DepoFoam bupivacaine,DepoDur,Exparel,Zynrelef和NeuroCuple,可显著降低疼痛评分和阿片类药物使用.
科学领域:
- 整形外科手术 整形外科手术
- 纳米技术纳米技术
- 疼痛管理 疼痛管理
背景情况:
- 手术后的疼痛是骨科手术中的一个重大挑战.
- 目前的疼痛管理策略通常依赖于全身阿片类药物,导致副作用.
- 新的药物输送系统为改善局部疼痛控制提供了潜力.
研究的目的:
- 审查各种纳米技术平台在骨科手术后的术后疼痛管理中的有效性.
- 评估这些平台对疼痛评分和止痛药需求的影响.
主要方法:
- 对评估纳米技术平台的研究进行叙述性审查:DepoFoam bupivacaine,DepoDur (延长释放的外周末末啡),Exparel,Zynrelef和NeuroCuple.
- 对临床试验数据的分析,将这些平台与安慰剂或骨科手术的标准治疗方法进行比较,例如骨髓切除术,全关节整形术和全膝关节整形术.
主要成果:
- 德波 (DepoFoam) 布皮瓦卡因显示,在骨髓切除术后疼痛得分降低.
- DepoDur显著减少了阿片类药物的使用,并延长了关节整形术后第一剂阿片类药物的时间.
- 在膝关节整形术后,Exparel改善了疼痛评分和减少了阿片类药物消费.
- 辛瑞莱夫在骨髓切除术后降低了疼痛强度和阿片类药物消耗.
- NeuroCuple设备减少了在休息和运动后的膝盖和关节整形术后的术后疼痛.
结论:
- 纳米技术平台在骨科手术后有效控制术后疼痛方面显示出显著的潜力.
- 这些平台提供优势,例如减少疼痛强度,改善疼痛评分,减少对全身阿片类药物的依赖.
- 这些先进的药物输送系统的进一步研究和临床应用是有必要的,以改善患者的康复.
相关概念视频
01:25Analgesia and Pain Management
1.5K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.5K
01:29Blood and Nerve Supply to the Bones
13.5K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
13.5K
01:44Nociception
33.0K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
33.0K