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特定亚型的NK细胞-TAM相互作用在HNSCC中驱动了一种新的预后特征

Zhenyan Zhao¹, Xuejiao Han¹, Yating Hu¹

¹State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, China.

Frontiers in immunology

|November 3, 2025

概括

这项研究揭示了自然杀手 (NK) 细胞和瘤相关巨细胞 (TAMs) 在头角状细胞癌 (HNSCC) 之间的特定相互作用. 一种新的基因特征 (CINT) 可以预测患者的预后和免疫治疗反应.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
基因组学就是基因组学.

背景情况:

头部和部状细胞癌 (HNSCC) 具有复杂的免疫微环境.
在HNSCC中,自然杀手 (NK) 细胞和瘤相关巨细胞 (TAM) 之间的相互作用机制尚不清楚.

研究的目的:

通过使用多omics分析,研究细胞异质性,相互作用模式和HNSCC中NK-TAM交叉声的预后意义.
识别特定的NK和TAM子集及其通信通路.
开发一个患者结果和免疫疗法反应的预测模型.

主要方法:

使用免疫组织化学,单细胞RNA测序和公共数据库分析了58个HNSCC组织样本.
使用CellChat推断连接体-受体相互作用,并通过CSOmap算法进行空间近距离评估.
使用LASSO Cox回归在独立队列中的预后模型的构建和验证.

主要成果:

鉴定出不同的NK细胞子集 (IL32+,NFKBIA+,STMN1+) 和TAM子集 (APOE+,IL1B+/CXCL10+,HSP+).
IL32+ NK细胞通过SPP1,MIF和ITGB2通路与APOE+ TAMs和CXCL10+ TAMs显著交叉.
一个23基因NK-TAM相互作用特征 (CINT) 有效地分层患者的风险和预测免疫治疗的生存益处.

结论:

特定亚型的NK-TAM相互作用在HNSCC进展中起着至关重要的作用.
该CINT签名作为一个强大的预后生物标志物和免疫治疗反应的预测器.
针对NK-TAM交叉对HNSCC来说是一个潜在的治疗策略.

关键词:

在 NK 细胞中,NK 细胞是 NK 细胞.细胞相互作用细胞相互作用头部和部状细胞癌瘤预测模型的预测模型.瘤微环境是一个微环境.与瘤相关的巨细胞.

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