类风湿性关节炎病原体中的牙周病变细菌:将临床关联与分子机制联系起来
Xiaojing Guo1,2,3, Siwei Wang1,2,3, Jiuli Ding3
1Department of Infectious Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Frontiers in immunology
|November 3, 2025
概括
牙周炎是一种口腔炎症疾病,与类风湿性关节炎 (RA) 有共同的联系. 这篇评论探讨了口腔细菌如 Porphyromonas gingivalis 如何通过炎症和免疫反应引发或恶化 RA.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 类风湿病学 类风湿病学
背景情况:
- 牙周炎 (PD) 是一种慢性炎症性口腔疾病,与微生物失衡有关.
- 类风湿性关节炎 (RA) 是一种由抗素蛋白抗体 (ACPA) 标志的自身免疫性疾病.
- 病发病和RA之间的临床和血清学联系表明了共享的致病机制.
研究的目的:
- 审查口腔微生物群和免疫反应在RA病变发生中的作用.
- 探索临床途径,将口腔病原体与RA关节炎联系起来.
- 审查有关牙周病原体对RA影响的机制研究,并讨论预防/治疗.
主要方法:
- 对口腔微生物群,免疫反应和RA研究的文献综述.
- 对临床和机械研究的分析,研究RA中的牙周病原体.
- 对 Porphyromonas gingivalis 和它在 RA 发展中的作用的综合发现.
主要成果:
- 在RA患者的关节中发现了牙周病原体,包括P. gingivalis.
- 关节炎患者表现出改变的口腔微生物群,增加了牙周炎相关的细菌.
- 牙周杆菌可以诱导素化,自身抗体的产生,以及炎症,加剧关节损伤.
结论:
- 口腔细菌,特别是P. gingivalis,可能在RA发病和进展中起因作用.
- 需要进一步研究牙周病和RA治疗对口腔微生物群的影响.
- 大规模的临床试验至关重要,以确认牙周病原体和RA之间的因果关系.
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