流感相关的肺阿斯伯吉洛症的临床特征:一项回顾性多中心队列研究
Jia-Xin Shi1, Xiang-Rong Shao1, Peng Wu2
1Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, China.
Frontiers in cellular and infection microbiology
|November 3, 2025
概括
流感相关的肺阿斯伯吉洛症 (IAPA) 是一种严重的疾病,经常影响免疫能力强的个体. 这项研究确定了糖尿病和淋巴衰竭是关键的危险因素,并强调了用于更好地检测和管理IAPA的先进诊断工具.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 流感相关的肺炎 (IAPA) 是一个重大的临床挑战,患病率和死亡率很高,特别是在严重的流感病例中.
- 与侵袭性肺阿斯伯吉洛症 (IPA) 不同,IAPA 经常发生在免疫能力强的宿主中,由于缺乏特定表现而使诊断复杂化.
- 了解IAPA的临床特征对于改善临床实践和患者结果至关重要.
研究的目的:
- 为了阐明IAPA的临床特征.
- 确定与IAPA开发相关的风险因素.
- 评估IAPA的诊断方法和预后指标,以支持临床管理.
主要方法:
- 进行了一项回顾性多中心队列研究.
- 收集的数据包括临床特征,危险因素,诊断方法 (包括银河,Aspergillus培养,M-ROSE和tNGS),治疗和预后.
- 进行了统计分析,以确定显著的关联和预测值.
主要成果:
- 糖尿病和淋巴缺血被确定为IAPA的显著风险因素.
- 肺部成像显示IAPA患者中结节和腔内病变的患病率较高.
- 像BALF galactomannan,M-ROSE和tNGS这样的诊断测试显示了对Aspergillus检测的高灵敏度和特异性.
- 中性粒细胞与淋巴细胞的比率 (NLR) 有效地预测了IAPA预后,截止值为17.70.
结论:
- 糖尿病和淋巴缺血是IAPA的关键风险因素.
- 综合使用血清/BALF银河,M-ROSE和tNGS显著提高了阿斯伯吉路斯检测率.
- 中性粒细胞与淋巴细胞的比率是IAPA患者的宝贵预后生物标志物.
相关概念视频
Pneumonia I: Introduction
713
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
713
COPD: Pathogenesis and Clinical Features
1.7K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.7K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.1K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.1K
Pneumonia III: Complications and Assessment
772
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
772
Pneumonia II: Pathophysiology
2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
298
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
298


