反映网络内大脑状态的大脑动态与创伤后早期创伤后期增加的创伤后应激症状有关
Mohammad Se Sendi1,2,3,4, Zening Fu4, Nathaniel G Harnett1,2
1Division of Depression and Anxiety, McLean Hospital, Belmont, MA, 02478, USA.
Nature. Mental health
|November 3, 2025
概括
创伤后的早期大脑网络动态预测创伤后压力 (PTS) 症状严重程度. 这些大脑连接模式与当前和未来的PTS结果有关,在女性中观察到更强烈的关联,突出了创伤反应中的性别差异.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 创伤研究 创伤研究
背景情况:
- 创伤后应激症 (PTS) 涉及对创伤的心理反应,可能导致创伤后应激障碍 (PTSD).
- 早期识别神经成像生物标志物对于理解PTSD风险和开发干预措施至关重要.
- 动态功能网络连接 (dFNC) 提供了关于创伤事件后大脑功能的见解.
研究的目的:
- 为了调查dFNC与创伤暴露后个体当前/未来PTS症状严重程度之间的关联.
- 探索性对大脑网络动态和PTS症状严重程度之间的关系的影响.
- 为了确定潜在的早期神经成像生物标志物用于PTSD风险评估.
主要方法:
- 纵向研究设计分析了来自275名参与者的dFNC数据,大约是创伤后2周.
- 统计分析将特定的网络间和网络内部大脑状态动态与PTS症状严重程度相关联.
- 检查观察到的关联中的基于性别的差异.
主要成果:
- 在网络间大脑状态动态和当前 (r=-0.197) 和未来 (r=-0.176) PTS症状严重程度之间发现了负相关性.
- 在网络内大脑状态动态和未来PTS症状强度 (r=0.205) 之间观察到正相关性.
- 网络动态与症状严重程度之间的关联在女性中更为明显,这表明性别差异很大.
结论:
- 创伤后早期的大脑网络动态与当前和未来的PTS症状严重程度有关.
- 特定的dFNC模式可以作为PTSD风险的早期生物标志物.
- 性差异在对创伤的神经生物学反应中起着至关重要的作用,女性在大脑动态和症状严重程度之间表现出更强烈的关联.
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