炎症-营养复合指数与卵巢内膜瘤之间的关系:一项回顾性观察性研究
Yan Zhang1, Ni Mei Zeng1, Jing Yi Fan1
1Physical Examination Center, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, People's Republic of China.
Journal of inflammation research
|November 3, 2025
概括
简单的炎症和基于营养的标志物可以帮助预测卵巢内膜瘤 (OMA). 中性粒细胞百分比/白蛋白-球蛋白比率 (NP/AGR) 显示出最高的预测值,有助于早期诊断子宫内膜异位症.
科学领域:
- 生殖医学 生殖医学
- 炎症性疾病 炎症性疾病
- 生物标志物发现发现
背景情况:
- 子宫内膜异位症是一种慢性炎症性疾病,经常面临诊断延迟,影响妇女的健康和生活质量.
- 卵巢内膜瘤 (OMA) 是内膜异位症最常见的亚型,需要早期检测方法.
- 简单的预测指标对于查高风险个体和促进及时治疗子宫内膜异位症至关重要.
研究的目的:
- 为了评估炎症和炎症-营养复合指数的预测性表现,在生育年龄的中国妇女中对OMA进行评估.
- 确定用于早期OMA查和诊断的简单,非侵入性标记物.
主要方法:
- 一项病例控制研究,涉及333名OMA妇女和506名对照.
- 炎症指数 (NLR,PLR,SII) 和炎症-营养复合指数 (NPAR,NLR/AGR,PLR/AGR,SII/AGR,NP/AGR) 的计算.
- 多变量逻辑回归和ROC曲线分析以评估关联和预测值.
主要成果:
- 与对照组相比,OMA患者的炎症和炎症-营养指数显著增加.
- 这些指数的高三位数与增加的OMA风险相关 (P <0.01).
- 中性粒细胞百分比/白蛋白-球蛋白比率 (NP/AGR) 显示出最高的预测性表现,AUC为0.799.
结论:
- 炎症-营养复合指数 (NPAR,NLR/AGR,PLR/AGR,SII/AGR,NP/AGR) 为OMA提供了有价值的,非侵入性的和具有成本效益的诊断潜力.
- 这些综合指数单独在预测OMA方面优于传统的炎症标志物.
- NP/AGR成为卵巢内膜瘤最有前途的预测因子.
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