黄素作为肠肝轴调节剂:MAFLD的新兴治疗策略
Mengxuan Hao1,2,3, Zihui Wang1,2, Liren Wang4
1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, China-Singapore Belt and Road Joint Laboratory on Infection Research and Drug Development, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
黄类药物对通过与肠道微生物相互作用来治疗与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 有希望. 这些天然化合物提供多目标机制来减少肝脏脂肪,炎症和纤维化.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 与代谢功能障碍相关的脂肪肝病 (MAFLD) 影响全球25%的成年人,治疗选择有限.
- 像黄素这样的天然化合物通过肠肝轴为MAFLD提供了潜在的治疗益处.
- 了解黄胺-肠道微生物群相互作用对于开发新型MAFLD治疗至关重要.
研究的目的:
- 系统地审查黄素和肠道微生物群在MAFLD中的作用.
- 阐明黄类药物在改善MAFLD中的多目标机制.
- 探索基于黄胺的MAFLD干预措施的创新策略.
主要方法:
- 对黄类药物,肠道微生物群和MAFLD进行的临床前和临床研究的系统审查.
- 分析黄酸的结构多样性和微生物生物转化.
- 检查由黄素调节的关键信号通路 (例如,PPARα,Nrf2,NF-κB).
主要成果:
- 黄类药物通过肠-肝轴调节肝脂代谢和免疫-炎症反应.
- 肠道微生物的黄类生物转化会影响它们在MAFLD的疗效.
- 黄类药物向多种途径,以减少脂质积累,氧化应激,炎症和纤维化.
结论:
- 黄类药物代表了对MAFLD管理的安全,有效,多目标的解决方案.
- 黄类-益生菌协同作用,纳米技术和个性化营养增强了治疗潜力.
- 需要进一步的临床研究,以将基于黄类的干预措施纳入常规实践.
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