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新辅助治疗对黑色素瘤患者生存结果的影响:系统性审查和元分析
Fan Yuan1, Mingyi Jing2, Xinlong Chen1
1Department of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province 610072, China.
EClinicalMedicine
|November 3, 2025
概括
新辅助疗法 (NT) 对黑色素瘤患者有前途,改善了生存率和反应率,但没有增加严重的副作用. 需要进一步的研究来证实这些好处在晚期皮肤癌.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 临床试验 临床试验
背景情况:
- 黑色素瘤是一种侵袭性皮肤癌,由于转移,往往呈现出不良预后.
- 新辅助疗法 (NT) 正成为固体瘤的潜在治疗方法,但其在黑色素瘤中的作用仍在调查中.
- 这项研究评估了在黑色素瘤患者中NT的疗效和安全性.
研究的目的:
- 评估黑色素瘤中新辅助治疗的完整响应 (CR) 率.
- 评估与NT相关的生存结果,包括与NT相关的总生存 (OS) 和无进展生存 (PFS).
- 确定NT的安全概况,重点关注不良事件 (AE).
主要方法:
- 对黑色素瘤的新辅助疗法研究的系统审查和元分析.
- 在主要数据库 (PubMed,Embase,Web of Science,Cochrane) 进行的搜索截至2025年2月.
- 包括随机对照试验和非随机研究,并对病理完整反应 (pCR),放射性完整反应 (rCR),OS,PFS和AE进行元分析.
主要成果:
- 对2821名患者的43项研究的分析显示,聚合PCR为33%,rCR为11%.
- 3级以上不良事件的发生率为33%.
- 与仅使用辅助剂的治疗相比,新辅助疗法显示PFS (HR=0.58) 和OS (HR=0.64) 的改善,严重AE发生率相似.
结论:
- 黑色素瘤的新辅助疗法与有利的完全响应率和有希望的生存益处有关.
- 在减少疾病进展和死亡率方面,NT显示出与仅辅助疗法相比的潜在优势.
- 需要高质量的随机试验来验证黑色素瘤中新辅助疗法的长期疗效和安全性.
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