在ALSPAC队列中的血压变化和不良怀孕和心血管结果
Milly Wilson1, Ashwini Elanko1, Hiten Mistry1
1Department of Women and Children's Health, School of Life Course and Population Sciences, Faculty of Medicine King's College London London UK.
Journal of the American Heart Association
|November 3, 2025
概括
怀孕期间的血压变化 (BPV) 与不良的孕产妇和产周期结局有关,特别是严重的高血压和产前. 然而,这次访问的BPV并不能预测母亲的长期心血管风险.
科学领域:
- 产科和妇科 产科和妇科
- 心血管医学 心血管医学
- 围产期健康 围产期健康
背景情况:
- 在怀孕期间以外的血压变化 (BPV) 是心血管事件的已知预测因素.
- 怀孕期间每次拜访的BPV与孕产妇/产前结果以及长期孕产妇心血管健康之间的关联尚未完全阐明.
研究的目的:
- 为了研究怀孕期间每次访问血压变化 (BPV) 与孕产妇/产周期不良结果之间的关联.
- 评估产前拜访对拜访BPV与长期母亲心血管结果之间的关系.
主要方法:
- 来自Avon长度父母与儿童研究 (ALSPAC) 的数据的二次分析,涉及12,509名女性.
- 使用后勤回归来检查BPV测量 (SD,平均真实变化,独立于平均值的变化) 与怀孕结果之间的关联.
- 考克斯回归被用来评估BPV测量和长期母亲结果之间的联系,包括高血压,糖尿病和心脏病.
主要成果:
- 在怀孕期间,通过SD和独立于平均值的可变性来测量,怀孕期间每次访问的BPV增加与不良妊娠结果显著相关,特别是严重的高血压和先兆子 (aORs 1.30-2.11).
- 在怀孕期间的BPV与母亲患高血压,糖尿病或心脏病的发展之间没有发现显著的关联,平均随访22年.
结论:
- 在产前检查期间的血压变化是识别短期不良妊娠结果风险的重要指标.
- 产前拜访对拜访BPV似乎没有长期的效用,在预测母亲的未来心血管风险.
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