炎症和认知衰退:在患有心房的老年成年人中进行的一项基于人口的队列研究
Danielle Marion1, Zhe Li2, Austyn Roseborough3
1School of Epidemiology and Public Health University of Ottawa Ottawa ON Canada.
Journal of the American Heart Association
|November 3, 2025
概括
较高的C-反应蛋白 (CRP) 水平与患有心房动 (AF) 的老年男性的认知能力下降有关. 这表明炎症可能会影响血脑屏障,影响这个人群中的大脑健康.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 前庭动 (AF) 与认知能力下降有关,但潜在的机制尚不清楚.
- 像C反应蛋白 (CRP) 这样的炎症标志物可能会增加血脑屏障 (BBB) 的透性,可能导致神经炎症.
- 这项研究调查了CRP,认知障碍和老年AF成年人死亡率之间的关联.
研究的目的:
- 为了检查基线C-反应蛋白 (CRP) 水平和老年成人心房 (AF) 认知障碍之间的关系.
- 评估该队列中CRP水平和死亡率之间的关联.
- 确定认知轨迹及其与CRP水平的关系,考虑到性别差异.
主要方法:
- 从REGARDS队列中分析了2109名患有AF流行的成年人 (≥45岁) 的数据.
- 使用六项选器测量血CRP的基线和年度认知状态.
- 应用竞争风险的Cox比例风险回归和潜伏类增长模型,以性别进行调整.
主要成果:
- 两倍的CRP与增加的死亡率 (HR 1.13) 相关,但没有发生的认知障碍 (HR 0.98).
- 确定了两个认知轨迹:91%的稳定性和9%的渐进性衰退.
- 患有较高CRP的男性表现出渐进性认知衰退的几率增加 (OR 1.09),与女性不同 (OR 1.04).
结论:
- 升高的CRP水平与AF的老年男性的认知障碍有关.
- 炎症介导的血脑屏障功能障碍是将AF与认知衰退联系起来的潜在途径.
- 在AF患者中,CRP与认知衰退之间的关联存在性别特异.
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