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视网膜毛细管密度和视网膜厚度在糖尿病视网膜病变中的关联

Rose Tan¹, Anoush Shahidzadeh², Ana Collazo¹

¹Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland, United States.

Investigative ophthalmology & visual science

|November 3, 2025

概括

视网膜毛细管的密度和厚度在健康的眼睛中是相关的,但在糖尿病视网膜病变 (DR) 中不是. 糖尿病视网膜病变显著降低组织输液密度,主要是由于血管密度下降.

科学领域:

眼科医生眼科眼科
医疗成像医学成像
糖尿病视网膜病变研究研究

背景情况:

糖尿病视网膜病变 (DR) 是导致视力丧失的主要原因.
了解DR中的微血管变化对于早期检测和管理至关重要.
光学连贯断层扫描血管造影 (OCTA) 允许对视网膜血管系统进行非侵入性可视化.

研究的目的:

在DR患者中研究视网膜血管密度和视网膜厚度 (RT) 之间的关系.
为了比较糖尿病人和非糖尿病人之间的这些关系.
评估DR严重程度如何影响视网膜血管指标.

主要方法:

从147名参与者 (44名对照,103名DR) 获得了OCTA扫描.
视网膜厚度 (全,表面,深) 和血管骨密度 (VSD) 被量化.
组织 perfusion 密度 (TPD) 被计算为 VSD/RT,并根据混因素进行调整.

主要成果:

毛细血管VSD和TPD显著降低,随着DR严重程度的增加.
在研究组之间没有观察到完全RT的显著差异.
在对照组中,VSD和RT之间的显著关联在DR患者中不存在或减弱.

结论:

视网膜毛细管密度和厚度之间存在着强烈的相关性,在健康的眼睛中存在,但在DR中减少了.
在DR中减少的TPD主要是由视网膜毛细血管密度下降所驱动的.
这些发现突出了DR中的微血管变化及其对视网膜结构的影响.

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