身体炼改善了与代谢功能障碍相关的脂肪性肝病患者的神经认知
Berenice Monserrat Román-Calleja1, Astrid Ruiz-Margain1, Andres Duarte-Rojo2
1Hepatology and Liver Transplant Division, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México.
概括
定期炼可显著提高大脑血流和认知功能,与代谢功能障碍相关的脂肪肝疾病 (MASLD) 患者. 这项研究表明,监控的运动计划改善了MASLD患者的关键健康标志物.
科学领域:
- 心血管医学 心血管医学
- 神经学 神经学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MASLD) 影响肝脏和身体组成.
- 在MASLD患者中,大脑血动力学和认知功能的影响尚不清楚.
- 众所周知,在MASLD中,运动有利于肝脏和身体组成.
研究的目的:
- 评估16周监测运动干预对肥胖MASLD患者大脑血液动力学和认知功能的影响.
- 为了比较饮食加运动组和仅饮食对照组之间的结果.
主要方法:
- 在40名肥胖MASLD患者的随机临床试验中.
- 干预组:饮食加上监控的运动 (增加步数,抵抗训练).
- 控制组:只有饮食. 两组人都有相似的认知参与活动.
主要成果:
- 运动组显示大脑血液动力学有所改善 (减少外围动脉硬性,抵抗指数,脉动性指数).
- 在运动组观察到显著的认知功能改善 (增加了MoCA和Addenbrooke分数).
- 两组人都减少了BMI和身体脂肪,运动组的减少更大.
结论:
- 一个结构化,监控的炼计划有效地改善了MASLD患者的大脑血液动力学和认知功能.
- 运动干预为MASLD患者提供了除了饮食之外的额外好处.
- 研究结果强调了运动在管理MASLD并发症方面的重要性.
相关概念视频
Exercise and Cardiovascular Response
3.8K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
3.8K
Liver Physiology
3.4K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.4K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
157
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
157
Exercise and Cardiac Output
1.8K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
1.8K
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
193
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
193
Liver Regeneration
4.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.2K


