破坏细菌膜的抗微生物可以减少的沙门氏菌殖民
Gary Closs1,2, Dipak Kathayat2,3, Yosra A Helmy2,4
1Department of Food Science & Technology, The Ohio State University, Columbus, Ohio, USA.
Microbiology spectrum
|November 3, 2025
概括
拉科巴西勒斯 (Lactobacillus rhamnosus) GG衍生的可以在实验室和中对沙门氏菌具有有效性. 这些抗微生物为控制家禽沙门氏菌的抗生素提供了有希望的替代品,提高了食品安全.
科学领域:
- 食品安全 食品安全
- 微生物学 微生物学
- 动物健康 动物健康
背景情况:
- 沙门氏菌构成严重的食品安全和公共卫生风险,主要通过家禽产品传播.
- 目前用于控制沙门氏菌的抗生素使用有助于抗菌素耐药性.
- 由于耐药性较低的发展,抗菌 (AMP) 正被探索为替代品.
研究的目的:
- 评估乳酸菌 GG (LGG) 衍生小对沙门氏菌Typhimurium (ST) 和沙门氏菌Enteritidis (SE) 的疗效.
- 评估这些的潜力,作为家禽抗生素的替代品.
- 为了确定的稳定性,在与家禽业相关的条件下.
主要方法:
- 在体外测试LGG衍生 (P1,P2,P4) 针对各种沙门氏菌血清病毒.
- 在体内对的疗效研究受到沙门氏菌Typhimurium的挑战.
- 对肉肉微生物群落的酸效应的分析.
- 在热和蛋白酶处理后评估稳定性.
主要成果:
- P1,P2和P4在体外显著抑制了ST,SE和其他沙门氏菌血清型.
- P1和P2分别减少了中的ST殖民量2.2和1.8日志.
- 酸没有对肉肉微生物群产生不利影响.
- 在暴露于热量和蛋白质酶后,类保留了活性,这表明它适合用于家禽应用.
结论:
- 来自LGG的小是有效的对沙门氏菌在体外和体内.
- 这些体代表了控制家禽沙门氏菌感染的有希望的策略.
- 这些发现支持开发AMP作为抗生素的替代品,改善食品安全和公共卫生.
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