内部自组装的皮克林介质细胞由负电荷的乳酸铁素稳定
Yi Li1, Brent S Murray1, Célia Ferreira1
1Food Colloids and Bioprocessing Research Group, School of Food Science and Nutrition, University of Leeds, Leeds, West Yorkshire LS2 9JT, United Kingdom.
Langmuir : the ACS journal of surfaces and colloids
|November 3, 2025
概括
乳二稳定了含有液晶相的新型半体体,为潜在的应用提供了增强的稳定性和保持内部结构.
科学领域:
- 材料科学 材料科学 材料科学
- 合体和表面科学科学
- 生物物理学的生物物理.
背景情况:
- 立方体液晶 (LLC) 中相是复杂的自组装结构,在药物输送和纳米技术中具有潜在的应用.
- 稳定这些微妙的中相,特别是在像中相体这样的乳液系统内,带来了重大挑战.
- 乳酸 (LF) 是一种天然存在的蛋白质,已成为合体系统的潜在生物相容稳定剂.
研究的目的:
- 为了设计稳定的亚微米乳液 (半体体) 封装各种LLC半相,使用乳酸铁素 (LF) 作为皮克林稳定剂.
- 调查LF预处理 (超声波) 和加工条件 (pH) 对中体形成,表面电荷和稳定性的作用.
- 描述介质体内的内部LLC结构,并将LF的性能与传统稳定剂进行比较.
主要方法:
- 使用乳酸铁素 (LF) 作为皮克林稳定剂,为甘油单酸 (GMO) /油酸 (OA) 混合物制备半体体.
- 在乳化过程中LF的超声波预处理以防止聚合和高压超声波.
- 使用动态光散射 (DLS) 进行尺寸和稳定性, ζ表面电荷潜力,对焦显微镜用于LF吸附,以及小角度X射线散射 (SAXS) 用于内部中相结构的表征.
主要成果:
- LF成功地稳定了四种不同的LLC半相 (双连续立方体,反向六角形,反向状立方体,微乳液) 在半相体内.
- 介质体表现出187239nm的水力动力直径 (dH),由于LF吸附,具有显著的正面电荷 (ζ电位≤+30 mV).
- 工程化介质体表现出优异的长期稳定性 (>1个月),并保持了封装LLC介质体的结构完整性,与Pluronic F127稳定不同.
- 由LF稳定的纯GMO形成了具有本地Pn3m形态的立方体,而Pluronic F127则诱导了相变.
结论:
- 乳二烯是一种有效的皮克林稳定剂,用于创建稳定的,带正电荷的介质体,封装各种热液晶介质体.
- 这种LF稳定方法保留了LLC中相的内部层次结构,与Pluronic F127.7等常规稳定剂相比,它具有优势.
- 这些LF稳定型介质体有望在需要具有控制内部纳米结构的稳定体输送系统的领域进行先进的应用.
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