与肥胖相关的DNA甲基化对遗传和环境影响的纵向变化:一项为期5年的双胞胎研究
Xuanming Hong1,2, Ke Miao1,2, Weihua Cao1,2
1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China.
Molecular biomedicine
|November 3, 2025
概括
遗传因素显著影响与肥胖相关的DNA甲基化 (DNAm) 位点,随着时间的推移显示稳定性. 虽然这些部位的遗传性很高,但纵向下降,遗传在肥胖中发挥着关键作用.
科学领域:
- 表观遗传学和基因组学
- 肥胖问题研究研究
- 双胞胎研究 双胞胎研究
背景情况:
- 与肥胖相关的DNA甲基化 (DNAm) 位点 (CpG) 的可复制性很低.
- 涉及遗传和环境对与肥胖相关的DNAm产生贡献的机制需要进行调查.
研究的目的:
- 系统地识别和验证与肥胖相关的CpG.
- 评估这些CpG的遗传性及其纵向变化.
- 研究遗传和环境对肥胖和DNAm之间的稳定性和交叉关系的影响.
主要方法:
- 在PubMed,EMBASE和EWAS目录中对与肥胖相关的CPG进行系统的文献搜索.
- 使用中国双胞胎注册表 (n=1,074) 验证已识别的CPG.
- 结构方程建模 (SEM) 来评估CpG的遗传性和纵向变化 (n=308与5年后续).
主要成果:
- 2,603/892/28 确定了BMI/WC/WHR的CpG;493/149/8 得到了验证.
- 与肥胖相关的CpG的平均遗传率为0.34,在5年内从0.38降至0.31.
- 高遗传相关性 (0.74) 和低环境相关性 (0.19) 对纵向DNAm稳定性; 随着时间的推移,从肥胖到DNAm的显著遗传影响.
结论:
- 遗传因素在随着时间的推移,与肥胖相关的DNAm的稳定性中起着重要作用.
- 肥胖特征对DNAm具有持续的纵向遗传影响.
- 这些发现为与肥胖相关的DNAm提供了遗传证据,并突出了遗传影响对与肥胖相关的表观遗传修饰的持久影响.
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