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多发性硬化症的认知功能,重点关注脑干体积
Eline Van Doninck1,2, Anna-Victoria De Keersmaecker3,4, Marie D'hooghe5,6,7
1Department of Family Medicine and Population Health, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium. eline.vandoninck@uantwerpen.be.
脑干体积与多发性硬化症 (MS) 的认知障碍无关. 然而,像海马体和皮质等其他大脑区域的体积减少与MS患者的认知缺陷有关.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 认知神经科学 认知神经科学
背景情况:
- 大脑干在大脑-小脑网络中起着至关重要的作用,对认知至关重要.
- 多发性硬化症 (MS) 中大脑干体体积和认知功能之间的关联仍然未得到充分探索.
研究的目的:
- 研究大脑干体体积与MS认知障碍之间的关系.
- 用多发性硬化症简要国际认知评估 (BICAMS) 电池来评估认知表现.
主要方法:
- 分析了VOLUMS研究中143名多发性硬化患者的MRI数据.
- 进行了体积脑成像和脑干病变计数.
- 使用BICAMS评估认知功能,研究相关性和逻辑回归的关联.
主要成果:
- 在30.1%的参与者中观察到认知障碍.
- 脑干体体积和认知得分之间没有发现显著的相关性.
- 河马,丘脑,皮质和灰质的较低体积与认知障碍有关. 处理速度和口头记忆与皮质和灰质体积相关.
结论:
- 大脑干体积与MS的认知障碍没有直接关联.
- 在MS的认知障碍与其他大脑结构的减少有关,包括海马体,丘陵体和皮质.
- 疾病持续时间是MS认知障碍的重要预测因素.
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