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传统的加工方法通过黄素的PPAR-γ激活释放了黄果的抗原性潜力

Yiqi Yan^1,2,3, Tian Xie^1,4, Ran An¹

¹Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.

Bioresources and bioprocessing

|November 3, 2025

概括

的Perilla水果可以增强黄素的作用,黄素是一种化合物,通过激活PPAR-γ通路,有助于通过激活PPAR-γ通路从泡细胞中去除胆固醇. 这为预防动脉样硬化和心血管疾病提供了一种自然的方法.

科学领域:

生物化学生物化学
药理学药理学是指药理学的学科.
心血管研究研究心血管研究

背景情况:

泡细胞的积累导致动脉样硬化和心血管疾病.
过氧体增殖器激活受体玛 (PPAR-γ) 调节脂质代谢和炎症.
传统中医 (TCM) 处理可能会提高治疗效果,但机制尚不清楚.

研究的目的:

为了研究混合的Perilla水果在动脉样硬化中的增强疗效的分子基础.
探讨素的作用,一种通过炸增加的化合物,在调节泡细胞形成中的作用.
通过PPAR-γ通路阐明氨酸的作用机制.

主要方法:

分子对接和动力学模拟以评估素-PPAR-γ相互作用.
在体外研究中使用ox-LDL诱导的RAW264.7巨细胞.
对胆固醇排放,脂质积累和PPAR-γ通路蛋白质表达的分析.
使用GW9662.2进行药理抑制.

主要成果:

炸的Perilla水果显著增加了luteolin的含量.
素在关键残留物 (SER289,HIS323,PHE360,TYR473) 中与PPAR-γ结合.
氨酸促进胆固醇排放,并减少巨细胞中的脂质积累.
氨酸对PPAR-γ通路蛋白进行上调,这种作用被GW9662.2.阻断.

结论:

提供了对炸的Perilla水果增强疗效的机械洞察力.
素通过PPAR-γ通路作用,改善泡细胞的形成.
氨酸是一种有前途的天然化合物,用于动脉样硬化预防和心血管健康.

关键词:

泡细胞的泡细胞是如何形成的脂质调节脂质的调节在PPAR-γ中使用PPAR.佩里拉果的果实是佩里拉果.传统中国医药加工传统中国医学加工

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