白质量和皮质厚度的变化预测了青春期早期内化症状
Zsofia P Cohen1, Florence J Breslin2, Kara L Kerr1
1Department of Psychology, Oklahoma State University.
Journal of psychopathology and clinical science
|November 3, 2025
概括
左半球加速皮质稀疏和青少年白质量减少可能预测未来的内化症状. 这些神经生物学标志物可以帮助早期诊断和治疗精神健康障碍.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 青少年内化症状是一个重大的公共卫生问题.
- 了解内化症状的神经生物学基础对于早期干预至关重要.
- 需要进行纵向研究,以确定青少年心理健康的预测标志物.
研究的目的:
- 调查灰白质的全球结构变化是否预测青少年内化症状.
- 为了检查大脑结构的纵向变化和内化症状之间的预测关系.
- 在大量青少年群体中,确定潜在的神经生物学风险因素,以内化症状.
主要方法:
- 利用了来自青少年大脑认知发展研究的二次数据,包括6 564名参与者.
- 采用线性混合效应模型来分析结构性大脑指标和内化症状之间的关系.
- 在3年的时间内 (年龄为9/10至11/12),计算出皮层厚度和全球白质体积的百分比变化得分.
主要成果:
- 左半球皮质变薄预测了12/13岁时内化症状,无论是照顾者还是青少年报告.
- 全球白质量 (WMV) 预测了护理人员报告的内化症状,但不是年轻人.
- 在性方面没有发现任何显著的相互作用效应,这表明这些大脑行为关系在两性之间是一致的.
结论:
- 加快皮质稀疏,特别是在左半球,和较低的WMV与发展内化症状的风险增加有关.
- 这些全球神经生物学标志物可以作为青少年心理健康障碍的早期指标.
- 对神经生物学标记物的进一步研究对于改善青少年心理健康的早期诊断和治疗策略至关重要.
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