在食道形的内镜下膜剖析后,狭窄形成的风险分层
Kareem Khalaf1, Youstina Hanna1, Tomoyuki Nishimura1
1Division of Gastroenterology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
概括
在食道内镜下粘膜解剖 (ESD) 后形成狭窄性是常见的,特别是在较大的缺陷. 诸如周长卷入和深壁损伤等因素显著增加了狭窄风险,影响了患者的治疗结果.
科学领域:
- 胃肠病学 胃肠病学
- 内镜检查是指内镜检查.
- 手术瘤学手术瘤学
背景情况:
- 消化管内镜下粘膜解剖 (ESD) 是用于切除早期消化管瘤的最小侵入性技术.
- 狭窄形成是食道ESD后的一个显著并发症,可能导致食欲障碍并需要干预.
- 识别与狭窄发展相关的因素对于优化患者管理和结果至关重要.
研究的目的:
- 评估与食道ESD后狭窄发育相关的人口,临床,程序和组织病理因素.
- 确定ESD后食道狭窄的发生率和特征.
- 确定食道ESD后狭窄形成的独立预测因子.
主要方法:
- 2019年至2024年接受食道ESD的患者的回顾性队列研究.
- 数据收集包括患者的人口统计,病变特征,程序细节和组织病理学.
- 狭窄形成被定义为需要干预的症状性光线狭窄,并分析了促成因素和结果.
主要成果:
- 24%的患者出现紧缩,其中85%的患者无法通过标准胃镜.
- 缺陷缩率显著增加,缺陷周围涉及度更大 (缺陷周围涉及度为7.7%的<50%至57.7%的≥90%).
- 狭窄形成的独立预测因素包括缺陷周边参与 (OR 1.07),住院时间 (OR 1.88) 和深壁损伤 (OR 6.28).
结论:
- 在ESD后的食道狭窄形成与病变和程序特征密切相关.
- 更大的缺陷大小,深层壁面损伤和更长的住院时间是狭窄发展的关键预测因素.
- 进一步研究预防策略,包括手术内干预措施,如三氨酸注射和手术后的类固醇治疗方案,是有必要的.
相关概念视频
Esophageal Strictures-I: Introduction
622
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
622
Esophageal Strictures-II: Clinical Features and Management
408
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
408
Barrett Esophagus-I: Introduction
604
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
604
Barrett Esophagus-II: Clinical Manifestations and Management
760
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
760
Endoscopic Procedures I: Esophagogastroduodenoscopy
862
An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:
During an EGD, the endoscope can be used to:
862
Gastroesophageal Reflux Disease II: Clinical Features and Management
680
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
680


