NapRNAdb:用于napRNA发现和功能注释的多种存储库和分析平台
Jiajia Xuan1, Chunhua Xiao1, Yonglei Luo1
1MOE Key Laboratory of Tumor Molecular Biology and State Key Laboratory of Bioactive Molecules and Druggability Assessment, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Nucleic acids research
|November 3, 2025
概括
一个新的数据库,NapRNAdb,对40种物种的非封闭RNA (napRNAs) 进行了目录. 它揭示了napRNA多样性和相互作用,有助于基因表达调节研究.
科学领域:
- 基因组学和转录基因组学
- 生物信息学和计算生物学
背景情况:
- 超过75%的人类基因组转录非封闭RNAs (napRNAs),主要在基因表达调节中发挥作用.
- 虽然短的napRNAs具有定义的角色,但具有多种终端修饰的长 napRNAs的特征很差.
研究的目的:
- 为napRNA研究开发一个全面的数据库.
- 为了实现跨物种的napRNA转录组概况和分析.
主要方法:
- 开发NapRNAdb,集成人类和小鼠NAP-seq数据.
- 使用进化保护分析进行跨物种napRNA识别.
- 整合表达特征,次要结构和交互网络.
主要成果:
- NapRNAdb包含来自人类和老鼠的30708个napRNAs,其中38个物种中有197345个被识别出来.
- 该数据库包括各种napRNA类别,如ACA-napRNAs,CD-napRNAs和Pol3-napRNAs.
- NapRNAdb识别了涉及RNA修饰,RNA结合蛋白和与疾病相关的变异的相互作用网络.
结论:
- NapRNAdb为探索napRNAs的转录,结构,表达和功能景观提供了一个宝贵的资源.
- 该数据库促进了napRNA生物学的全面剖析,并加速了机械学的洞察力.
- NapRNAdb包括一个"PreTool"模块,用于评估napRNA处理潜力.
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