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Updated: Jan 12, 2026

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
08:14

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

Published on: August 28, 2018

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混合溶剂分子动力学模拟揭示了PCSK9 C-终端域中的可用于药物的体口袋

Sutanu Mukhopadhyay1, Suman Chakrabarty1

  • 1Department of Chemical and Biological Sciences, S. N. Bose National Centre for Basic Sciences, Salt Lake, JD Block, Sector 3, Bidhannagar, Kolkata, West Bengal 700106, India.

The journal of physical chemistry. B
|November 3, 2025
PubMed
概括

研究人员使用分子模拟在蛋白转化酶亚提利辛/素9型 (PCSK9) 中发现了一个新的可药性全位. 这一发现为开发治疗高胆固醇 (高胆固醇血症) 的疗法提供了新的策略.

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