在新生儿群体中使用抗菌素使用监测,使用定义的每日剂量方法
Paloma Suárez-Casillas1, Marta Mejías-Trueba1,2,3,4, Germán Peñalva2,3,4
1Department of Pharmacy, Hospital Universitario Virgen del Rocío, Seville, Spain.
Neonatology
|November 3, 2025
概括
新生儿每日确定的剂量 (DDDn) 是监测新生儿抗菌药物消耗的可行指标. 这种方法增强了抗菌药物管理计划 (ASP) 并优化了新生儿的抗生素使用.
科学领域:
- 新生儿药理学 新生儿药理学
- 抗微生物药物管理管理
- 公共卫生 公共卫生
背景情况:
- 新生儿群体需要标准化指标来监测抗微生物消费.
- 通过改善抗生素使用数据,可以增强现有的抗菌药物管理计划 (ASP).
- 新生儿每日定量 (DDDn) 为标准化测量提供了一个潜在的解决方案.
研究的目的:
- 评估使用新生儿定义每日剂量 (DDDn) 作为标准化指标的可行性.
- 为缺乏它们的抗微生物药物建立新的DDDn值.
- 改善新生儿护理中的抗菌药物管理.
主要方法:
- 在第三级护理教学医院新生儿科的观察性研究 (2016年1月至2023年12月).
- 关于抗微生物药物使用的未来数据收集.
- 使用了先前验证和新确定的DDDn值;消费量以每1000个占用床位日 (OBD) 的DDDn来衡量.
主要成果:
- 验证了10种抗微生物药物的DDDn,包括piperacillin-tazobactam,cefepime和amoxicillin-clavulanic acid.这些抗微生物药物包括在内.
- 全球平均抗菌药物消耗:5.271 ± 1.435 DDDn/1,000个OBD/年.
- 已确定的口服和静脉注射抗微生物药物的转换因子.
结论:
- DDDn是监测新生儿抗菌药物消费的可行工具.
- 标准化的DDDn指标可以增强ASP并优化抗生素使用.
- 需要进一步的研究来验证DDDn在不同的抗微生物药物和环境中.
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