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对IgG4相关的眼部疾病中不同皮质类固醇施用方法的体积反应的比较
Min Kyu Yang1, Seong Jung Ha1, Ho-Seok Sa1
1Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
静脉注射甲基prednisolone (methylPd) 和局部triamcinolone (TA) 注射显示优异的放射性反应IgG4相关的眼部疾病 (IgG4-ROD) 涉及眼腺相比,口服的普雷迪尼索隆 (Pd). 局部TA注射提供了可比且有效的替代治疗选择.
科学领域:
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 与IgG4相关的眼部疾病 (IgG4-ROD) 通常涉及眼腺扩大.
- 皮质类固醇是治疗的支柱,但最佳的施用途径需要进一步调查.
研究的目的:
- 为了比较不同的皮质类固醇给药方法对影响眼腺的IgG4-ROD的临床和体积反应.
- 为了评估口服普雷迪尼索隆 (Pd),静脉注射甲基普雷迪尼索隆 (methylPd) 和局部氨 (TA) 注射的疗效和耐久性.
主要方法:
- 对28名患有IgG4-ROD和双边眼腺扩大的患者病历的回顾性审查.
- 在口服Pd,IV甲基Pd和局部TA注射组中比较临床症状和非透析的眼腺体体积.
- 放射性复发定义为治疗后体积<1.0cm3或体积比率<35%.
主要成果:
- 静脉注射甲基普雷迪尼索隆 (IV甲基Pd) 组显示显著更高的2年无放射性复发存活率 (80.0%) 与口服普雷迪尼索隆 (Pd) 组 (37.5%) 相比.
- 局部氨 (TA) 注射组显示100%的无复发存活率,相当于IV甲基Pd.
- 在治疗后的一年后,IV甲基Pd组 (35.4%) 与口服Pd组 (75.0%) 相比,治疗后与治疗前的中位数体积比率显著较低.
结论:
- 静脉注射甲基prednisolone (IV甲基Pd) 在IgG4-ROD患者的眼腺参与提供优越和更持久的放射性反应比口服前列尼索隆 (Pd).
- 局部氨 (TA) 注射是一种有效的替代治疗选择,具有出色的放射性结果.
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