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Updated: Jan 12, 2026

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一个以碎片化行为为导向的UHPLC-Q-Orbitrap HRMS方法,用于对水中的26种 perfluoroalkyl物质及其替代品进行定量分析

Guojian Shao¹, Tao Liu¹, You Xia¹

¹Huzhou Center for Disease Control and Prevention, Key Laboratory of Emergency Detection for Public Health, Huzhou, China.

|November 3, 2025

概括

一种新的UHPLC-HRMS方法可以准确地检测到水中的26个per-和多基物质 (PFAS). 这种先进的技术有助于环境监测和持久化学品的风险评估.

科学领域:

环境化学环境化学
分析化学分析化学
毒理学毒理学毒理学

背景情况:

和多基基物质 (PFAS) 是持久性环境污染物,具有潜在的健康风险.
由于其持久性和生物积累,人们对传统和新兴的PFAS替代品存在全球关注.
强大的分析方法对于监测各种水源中的PFAS污染至关重要.

研究的目的:

开发和验证一种敏感和选择性的超高性能液体染色学-四极-轨道轨道高分辨率质谱法 (UHPLC-Q-轨道轨道 HRMS) 方法.
综合分析26种PFAS,包括 perfluorocarboxylic acid (PFCA), perfluorosulfonic acid (PFSA) 和它们的新兴替代品.
提供可靠的环境监测和风险评估工具,用于在各种水表中对 PFAS 的风险评估.

主要方法:

样本准备涉及WAX固体相提取与同位素标记的内部标准.
分离是在BEH C18柱上进行的.
量化分析使用了全MS,目标SIM和并行反应监测 (PRM) 模式.

主要成果:

经过验证的方法证明了出色的线性,子ng/L检测极限,以及在不同水矩阵中强大的回收和精度.
并行反应监测 (PRM) 提供了灵敏度和选择性之间的最佳平衡.
特征性的碎片化模式有助于结构确认,同位素分化和低丰度化合物的识别.

结论:

以碎片化为指导的UHPLC-HRMS方法能够高可靠性地检测和量化既旧的PFAS,又新的PFAS.
该方法为环境监测中全面的PFAS分析提供了实用和可靠的工具.
该研究有助于更好地了解和评估水生环境中PFAS风险.

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