对于老年人来说,在治疗决策中最重要的是:一个离散选择实验
Vera C Hanewinkel1, Hanneke van der Wal-Huisman2, Suzanne Festen3
1Department of Policy, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
PloS one
|November 3, 2025
概括
老年人优先考虑独立,避免疼痛/记忆问题,而不是面对严重疾病时延长预期寿命. 一个较小的群体更重视延长寿命,强调医疗决策中患者的不同偏好.
科学领域:
- 老年学是一门学科.
- 医疗决策的制定 医疗决策的制定
- 卫生经济学 卫生经济学
背景情况:
- 传统的医学决策往往侧重于疾病特异性结果,如生存率.
- 对于老年人来说,保持独立和生活质量比延长寿命同等或更重要.
- 了解社区老年人的优先事项对于优化治疗决策和医疗保健政策至关重要.
研究的目的:
- 确定50岁及以上的成年人在选择危及生命的疾病的假设治疗方法时的结果偏好.
- 探索预期寿命,独立,疼痛,记忆和社会成本等因素如何影响这些选择.
主要方法:
- 对333名50岁及以上的参与者进行了一项离散选择实验 (DCE).
- 参与者根据五个属性评估假设的治疗选择:预期寿命,独立性,疼痛,记忆问题和社会成本.
- 使用条件逻辑和隐性类分析来确定属性实用性和识别偏好子组.
主要成果:
- 大多数参与者优先考虑保持独立,其次是预期寿命和避免严重损伤.
- 预期寿命仅在延长至少两年时才被评估;社会成本也影响了选择.
- 隐性阶级分析揭示了两个子组:一个优先考虑预期寿命,另一个强调独立性和较低的社会成本.
结论:
- 大多数年龄在50岁以上的人面临危及生命的疾病优先考虑独立,并最大限度地减少严重的疼痛/记忆问题,而不是最大限度地延长预期寿命.
- 一个不同的子组优先考虑预期寿命,表明患者的偏好各不相同.
- 这些不同的偏好,包括社会成本,必须为个人治疗决策,临床指南和医疗保健政策提供信息.
相关概念视频
Pharmacodynamics in Geriatric Patients: Effects of Age
182
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
182
Drug Dosing: Geriatric Patients
217
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
217
Decision Making
876
Decision-making is a fundamental cognitive process that involves evaluating alternatives and selecting among them. This process can range from simple choices, such as deciding what to wear, to complex decisions, like choosing a major in college or a career path. The complexity of the decision often dictates the approach we use, which can be broadly categorized into two types: automatic and controlled decision-making.
Automatic decision-making is fast, intuitive, and relies on gut feelings...
Automatic decision-making is fast, intuitive, and relies on gut feelings...
876
Decision Making: Traditional Method
5.0K
The process of hypothesis testing based on the traditional method includes calculating the critical value, testing the value of the test statistic using the sample data, and interpreting these values.
First, a specific claim about the population parameter is decided based on the research question and is stated in a simple form. Further, an opposing statement to this claim is also stated. These statements can act as null and alternative hypotheses, out of which a null hypothesis would be a...
First, a specific claim about the population parameter is decided based on the research question and is stated in a simple form. Further, an opposing statement to this claim is also stated. These statements can act as null and alternative hypotheses, out of which a null hypothesis would be a...
5.0K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
229
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
229
Factorial Design
13.7K
Factorial Analysis is an experimental design that applies Analysis of Variance (ANOVA) statistical procedures to examine a change in a dependent variable due to more than one independent variable, also known as factors. Changes in worker productivity can be reasoned, for example, to be influenced by salary and other conditions, such as skill level. One way to test this hypothesis is by categorizing salary into three levels (low, moderate, and high) and skills sets into two levels (entry level...
13.7K


